EFFECTS OF CONSUMING OF OYSTER EXTRACT DRINK CONTAINING 3,5-DIHYDROXY-4-METHOXYBENZYL ALCOHOL (DHMBA) ON STRESS, FATIGUE, AND SLEEP
Er Jin EIO1, Emiko MIKI1, Takayuki WATANABE1, Masanobu KATAGIRI1, Riko FUKUDA2, Yoshihiro URADE3, Mitsugu WATANABE1
1Watanabe Oyster Laboratory Co., Ltd. and 490-3, Shimoongata-Cho, Hachioji, Tokyo, Japan
2Hibiya Kokusai Clinic and 2-2-3 Uchisaiwaicho, Chiyoda-ku, basement 1 floor, Tokyo, Japan.
3International Institute for Integrative Sleep Medicine, University of Tsukuba and 1-1-1 Tennodai, Tsukuba, Ibaraki Japan.
Key words: oyster extract, stress, fatigue, sleep, 3,5-dihydroxy-4-methoxybenzyl alcohol
The oyster drink “Watanabe Oyster Drink” contains essential amino acids and trace metals as well as 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), a phenolic antioxidant. The aim of this study was to examine the effects of consuming of oyster extract drink containing 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) on stress, fatigue, and sleep in adult volunteers who felt stress and fatigue.
Total 84 healthy adults were recruited in a double-blind, placebo-controlled, parallel-group study. The participants were randomly divided into either the DHMBA-containing oyster extract drink (2 bottles) or placebo group. The respective test drinks were consumed daily for 4 weeks. The conditions of stress, fatigue, and sleep were evaluated by the Short form of Profile of Moods States (POMS-S), the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-j), and the Athens Insomnia Scale (AIS).
In POMS-S, the changes from pre-trial values of Depression score of oyster extract drink group at week 1 and week 4 was -17.5 ± 13.4 and -19.0 ± 11.8, respectively, the Fatigue score at week 1 and week 4 was -12.7 ± 10.4 and -16.5 ± 10.7, respectively, and the Confusion score at week 1 and week 4 was -13.2 ± 12.0 and -17.4 ± 12.5, respectively. The results showed that the Depression, Fatigue, and Confusion relieving effects of the DHMBA-containing oyster extract drink group increased with time of consumption. Furthermore, there was a significant improvement (P < 0.05) in self-reported of Depression, Vigor, Fatigue, and Confusion in DHMBA-containing oyster extract drink group than the placebo group. For validation, the Pittsburgh Sleep Quality Index Japanese version also showed significantly better (P < 0.05) in DHMBA-containing oyster extract drink group compared with placebo drink group. There were no adverse events related to the intake of the test drinks.
Our results suggest that the intake of DHMBA-containing oyster extract drink alleviates mental stress and fatigue, and improves sleep.